Omentin-1 Is Decreased in Maternal Plasma, Placenta and Adipose Tissue of Women with Pre-Existing Obesity

G Barker; R Lim; HM Georgiou; M Lappas

Journal article

Omentin-1 Is Decreased in Maternal Plasma, Placenta and Adipose Tissue of Women with Pre-Existing Obesity

G Barker, R Lim, HM Georgiou, M Lappas

Plos One | PUBLIC LIBRARY SCIENCE | Published : 2012

DOI: 10.1371/journal.pone.0042943

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Abstract

Objective: The aim of this study was to determine (i) the effect of maternal obesity and gestational diabetes mellitus (GDM) on (i) the circulating levels of omentin-1 in cord and maternal plasma, and (ii) gene expression and release of omentin-1 from human placenta and adipose tissue. The effect of pregnancy on circulating omentin-1 levels was also determined. Design: Omentin-1 levels were measured in maternal and cord plasma from obese and non-obese normal glucose tolerant women (NGT; n = 44) and women with GDM (n = 39) at the time of term elective Caesarean section. Placenta and adipose tissue expression and release of omentin-1 was measured from 22 NGT and 22 GDM women collected at the t..

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University of Melbourne Researchers

Harry Georgiou Author

Martha Lappas Author

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

Dr Martha Lappas was a recipient of a National Health and Medical Research Council (NHMRC) RD Wright Fellowship (grant no. 454777). The work described in this manuscript was funded by a project grant from the NHMRC (grant no. 454310). Funding for the iQ5 multicolour RT-PCR machine (in-part) and xMark Microplate Absorbance Spectrophotometer was provided by the Medical Research Foundation for Women and Babies. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.